Concise Synthesis of Broussonone A.

نویسندگان

  • Hyeju Jo
  • Minho Choi
  • Mayavan Viji
  • Young Hee Lee
  • Young-Shin Kwak
  • Kiho Lee
  • Nam Song Choi
  • Yeon-Ju Lee
  • Heesoon Lee
  • Jin Tae Hong
  • Mi Kyeong Lee
  • Jae-Kyung Jung
چکیده

A concise and expeditious approach to the total synthesis of broussonone A, a p-quinol natural compound, has been developed. The key features of the synthesis include the Grubbs II catalyst mediated cross metathesis of two aromatic subunits, and a chemoselective oxidative dearomatizationin the presence of two phenol moieties. Especially, optimization associated with the CM reaction of ortho-alkoxystyrenes was also studied, which are known to be ineffective for Ru-catalyzed metathesis reactions under conventional reaction conditions because ortho-alkoxy group could coordinate to the ruthenium center, resulting in the potential complication of catalyst inhibition.

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عنوان ژورنال:
  • Molecules

دوره 20 9  شماره 

صفحات  -

تاریخ انتشار 2015